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KMID : 0352720090330040330
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Journal of Ginseng Research
2009 Volume.33 No. 4 p.330 ~ p.336
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Effect of Ginsenoside Rb1 on Cell Adhesion, Surface Molecule Expression and Morphological Changes
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Kim Byung-Hun
Cho Jae-Youl
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Abstract
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Cell-cell adhesion managed by various adhesion molecules is known to be one of important phenomena found in numerous immunological responses or diseases such as immunostimulation, rheumatoid arthritis and allergic diseases. In this study, we examined the regulatory role of ginsenosides (G)-Rb1, reported to display immunostimulatory and anticancer effects, on cell adhesion, the up-regulation of surface adhesion molecules and morphological changes using monocytic U937 and macrophage-like RAW264.7 cells. G-Rb1 significantly up-regulated U937 cell-cell adhesion mediated by both CD29 and CD43. It also enhanced U937 cell-fibronectin adhesion, while CD29 blocking antibody P5D2 strongly suppressed it. In agreement, this compound also significantly increased the surface level of CD29 as well as CD43. Furthermore, this compound differentially modulated CD82 up-regulation and morphological changes triggered by lipopolysaccharide (LPS) and phorbol-12-myristate-13-acetate (PMA). Therefore, these results suggest that G-Rb1 may have differential modulatory function on cell adhesion events, surface molecule expression and morphological changes responsible for immune responses.
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KEYWORD
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ginsenoside Rb1, cell-cell adhesion, adhesion molecule, U937 cell, RAW264.7 cell
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